Cell adhesion-inhibiting antiinflammatory and...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 401/12 (2006.01) A61K 31/10 (2006.01) A61K 31/165 (2006.01) A61K 31/445 (2006.01) A61K 31/4545 (2006.01) A61K 31/496 (2006.01) A61K 31/5375 (2006.01) A61K 31/5377 (2006.01) A61P 29/00 (2006.01) A61P 37/06 (2006.01) C07C 323/62 (2006.01) C07D 211/66 (2006.01) C07D 295/16 (2006.01) C07D 295/26 (2006.01) C07D 413/12 (2006.01) C07D 491/113 (2006.01)

Patent

CA 2369238

The present invention relates to cinnamide compounds of formula (I), in which at least one of R1 to R5 is a "cis-cinnamide" (a) or a "trans-cinnamide" (b) and the other variables are as defined in the claims, that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds and to methods of inhibiting inflammation or suppressing immune response in a mammal.

L'invention concerne des composés cinnamide correspondant à la formule (I), dans laquelle R¿1? et/ou R¿5? désignent soit un "cis-cinnamide" (a) ou un "trans-cinnamide" (b), les autres variables étant spécifiées dans les revendications. Ces composés conviennent dans le traitement de maladies inflammatoires et immunes. L'invention concerne également des compositions pharmaceutiques contenant lesdits composés, ainsi que des techniques d'inhibition d'une inflammation ou de suppression de la réponse immunitaire chez un mammifère.

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