Cell adhesion inhibitors

Details Cell adhesion inhibitors Cell adhesion inhibitors

C - Chemistry, Metallurgy

07

D

C07D 405/06 (2006.01) A61K 31/40 (2006.01) A61K 31/4025 (2006.01) A61K 31/445 (2006.01) C07D 207/16 (2006.01) C07D 401/06 (2006.01) C07D 401/08 (2006.01) C07D 401/10 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 409/06 (2006.01) C07K 5/02 (2006.01) C07K 5/06 (2006.01) C07K 5/078 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2380817

A cell adhesion inhibitor of the general formula: R3-L-L'-R1 is disclosed. An inhibitor of the present invention interacts with VLA-4 molecules and inhibits VLA-4 dependent cell adhesion. Also disclosed are methods for preparing and using such a cell adhesion inhibitor, as well as pharmaceutical compositions containing the same.

L'invention concerne un inhibiteur d'adhésion cellulaire représenté par la formule générale suivante : R?3¿-L-L'R?1¿. Un inhibiteur selon la présente invention interagit avec des molécules de VLA-4 et inhibe l'adhésion cellulaire dépendant du VLA-4. L'invention concerne également des méthodes de préparation et d'utilisation d'un tel inhibiteur d'adhésion cellulaire, ainsi que des compositions pharmaceutiques le renfermant.

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