C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/12 (2006.01) A61K 31/085 (2006.01) A61K 31/09 (2006.01) A61K 31/17 (2006.01) A61K 31/195 (2006.01) A61K 31/335 (2006.01) A61K 31/34 (2006.01) A61K 31/38 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) A61K 31/535 (2006.01) A61K 31/55 (2006.01) A61K 45/00 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01) C07C 275/40 (2006.01) C07C 275/42 (2006.01) C07C 311/06 (2006.01) C07C 311/60 (2006.01) C07C 323/41 (2006.01) C07D 207/09 (2006.01) C07D 207/16 (2006.01) C07D 207/26 (2006.01) C07D 207/27 (20
Patent
CA 2261848
The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of using them for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. The compounds and pharmaceutical compositions of this invention can be used as therapeutic or prophylactic agents. They are particularly well-suited for treatment of many inflammatory and autoimmune diseases. In one aspect the invention provides a cell adhesion inhibitor having Formula (I) A-B (I) wherein A comprises a VLA-4 specificity determinant which does not impart significant IIb/IIIa activity, and B comprises an integrin scaffold derived from a compound having IIb/IIIa activity.
La présente invention concerne de nouveaux composés servant à l'inhibition et à la prévention de l'adhésion cellulaire ainsi que des pathologies induites par adhésion cellulaire. Cette invention concerne aussi des formulations pharmaceutiques comprenant de tels composés et leurs procédés d'utilisation pour l'inhibition et la prévention de l'adhésion cellulaire et des pathologies induites par adhésion cellulaire. Les composés et les compositions pharmaceutiques de ladite invention peuvent s'utiliser comme agents thérapeutiques ou prophylactiques. Ils conviennent tout particulièrement dans le traitement de nombreuses maladies inflammatoires et auto-immunes.
Adams Steven P.
Ensinger Carol L.
Zheng Zhongli
Biogen Inc.
Biogen Idec Ma Inc.
Smart & Biggar
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