Cell adhesion peptide

Details Cell adhesion peptide Cell adhesion peptide

C - Chemistry, Metallurgy

12

N

530/17, 195/34.1

C12N 11/08 (2006.01) C07K 17/02 (2006.01) C07K 7/10 (1990.01)

Patent

CA 1277265

CELL ADHESION PEPTIDE Abstract of the Disclosure The specification discloses a peptide including as the cell-attachment-promoting or cell-attachment- inhibiting constituent the amino acid sequence Arg-Gly- Asp-R wherein R is Ser, Cys, Thr or other amino acid or NH2, and the use of these peptides to alter the cell attachment activity of cells to various substrates. In one aspect the specification discloses a method for promoting cell attachment to a substrate comprising the steps of immobilizing on the substrate a non- naturally occurring polypeptide which includes as the cell-attachment-promoting constituent the sequence -Arg- Gly-Asp-R- wherein R is Ser, Cys, Thr or other amino acid or NH2, such that the polypeptide has cell-attachment- promoting activity; and providing free cells for attachment to said substrate. In another embodiment the present specification discloses a substantially pure peptide including as the cell-attachment-promoting constituent the amino acid sequence Arg-Gly-Asp-R wherein R is Ser, Cys, Thr or other amino acid, or NH2, said peptide having cell-attachment-promoting activity, and said peptide not being a naturally occurring peptide. In still a further embodiment the invention provides a peptide including as the cell-attachment-promoting constituent the amino acid sequence Arg-Gly-Asp-R, wherein R is Ser, Cys, Thr or other amino acid or NH2, such that the peptide has cell-attachment-promoting activity, wherein said peptide has less than about 31 amino acid residues. In still a further embodiment the invention provides a method of inhibiting platelet aggregation comprising providing a non-naturally occurring polypeptide which includes as the cell attachment-promoting constituent the sequence Arg-Gly- Asp-R wherein R is Ser, Cys, Thr or other amino acid or NH2 such that the polypeptide has cell-attachment- promoting activity.

471089

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