C - Chemistry – Metallurgy – 40 – B
Patent
C - Chemistry, Metallurgy
40
B
C40B 40/02 (2006.01) B01J 19/00 (2006.01) C12M 1/34 (2006.01) C12N 11/00 (2006.01) C12Q 1/02 (2006.01) C12Q 1/04 (2006.01) C12Q 1/68 (2006.01) G01N 1/36 (2006.01) G01N 33/50 (2006.01) G01N 33/543 (2006.01) G01N 33/554 (2006.01) G01N 33/567 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01) G06F 19/00 (2006.01)
Patent
CA 2394821
The present invention provides cell arrays comprising a plurality of tubes containing populations of cells that are immobilized therein. The arrays are particularly useful for conducting comparative cell-based analyses. Specifically, the subject arrays allow protein-protein interactions to he studied in multiple types of cell simultaneously. The arrays also support simultaneous detection of the differential expression of a target polynucleotide in a multiplicity of cell types derived from multiple subjects. The subject arrays further permit high throughput screening for candidate modulators of a signal transduction pathway of interest. Further provided by the invention are kits, computer-implemented methods and systems for conducting the comparative cell-based analyses.
L'invention porte sur des jeux de cellules consistant en séries de tubes contenant des populations de cellules y étant immobilisées. Lesdits jeux sont particulièrement utiles pour effectuer des analyses comparatives de cellules. Spécifiquement, lesdits jeux permettent d'étudier simultanément des interactions protéine-protéine dans plusieurs types de cellules. Lesdits jeux permettent également d'effectuer la détection simultanée de l'expression différentielle d'un polynucléotide cible dans une série de types de cellules provenant de différents individus. Ils permettent en outre d'effectuer des criblages à fort débit de modulateurs candidats de voies de transduction de signaux d'intérêt. L'invention porte également sur des trousses et des méthodes et systèmes informatisés d'analyses comparatives portant sur des cellules.
Li Ronghao
Mather Jennie P.
Biomosaic Systems Inc.
Borden Ladner Gervais Llp
Raven Biotechnologies Inc.
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