A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 39/395 (2006.01) C07K 14/47 (2006.01) C07K 19/00 (2006.01) G01N 33/567 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2383591
The present invention provides a whole-cell biological assay that measures changes of endogenous genes under control of an exogenously introduced transcription factor. The exogenous transcription factors of the present invention may be designed such that each is activated by specific extracellular ligands. Therefore cells containing exogenous transcription factors of the present invention provide a generic means to which many extracellular ligands may be tested without undue adaptation to the assay.
La présente invention concerne un dosage biologique d'une cellule entière qui permet de mesurer des changements de gènes endogènes sous contrôle d'un facteur de transcription introduit de manière exogène. Les facteurs de transcription exogènes de cette invention peuvent être conçus de manière à ce que chaque facteur est activé par des ligands extracellulaires spécifiques. De ce fait, des cellules renfermant des facteurs de transcription exogènes de cette invention produisent un moyen générique par rapport auquel plusieurs ligands extracellulaires peuvent être testés sans adaptation excessive du dosage.
Kelley Glenn L.
Mercolino Thomas J.
Siekierka John J.
Zhong Zhong
Zivin Robert
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Ortho-Mcneil Pharmaceutical Inc.
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