Cell-based detection and differentiation of disease states

Details Cell-based detection and differentiation of disease states Cell-based detection and differentiation of disease states

G - Physics

01

N

G01N 33/48 (2006.01) C07H 21/04 (2006.01) C12Q 1/04 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2498411

The present invention provides a method for detecting and differentiating disease states with high sensitivity and specificity. The method allows for a determination of whether a cell~based sample contains abnormal cells and, for certain diseases, is capable of determining the histologic type of disease present. The method detects changes in the level and pattern of expression of the molecular markers in the cell-based sample. Panel selection and validation procedures are also provided.

La présente invention concerne une méthode permettant de détecter et de différentier des états pathologiques avec un degré de sensibilité et de spécificité élevé. Avec cette méthode, il est possible de déterminer si un échantillon cellulaire contient des cellules anormales et, pour certaines maladies, de déterminer le type histologique. La méthode permet de détecter des changements de niveau et de mode d'expression de marqueurs moléculaires dans l'échantillon cellulaire. Sont également décrites des méthodes de sélection et de validation.

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