Cell-based detection of apf through its interaction with...

Details Cell-based detection of apf through its interaction with... Cell-based detection of apf through its interaction with...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C07H 21/04 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2747244

An assay system designed to detect a protein biomarker in urine that is diagnostic for interstitial cystitis (IC). The presence of a 9 amino acid glycopeptide, antiproliferative factor (APF), in urine is unique to patients with IC. Urine samples from patients who exhibit symptoms consistent with IC are added to the assay system. Binding of APF to the cytoskeletal associated protein 4 (CKAP4) is positive for the presence of APF in urine and diagnostic for IC. The diagnostic system is a significant and surprising advance in diagnosis of IC and has commercial applications relevant to women and men who suffer from symptoms consistent with IC.

L'invention concerne un système d'essai conçu pour détecter un biomarqueur de protéine dans l'urine qui est diagnostiqué pour la cystite interstitielle (IC). La présence d'un facteur antiprolifératif (APF), le glycopeptide de 9 acides aminés, dans l'urine est spécifique aux patients souffrant de cystite interstitielle. Les échantillons d'urine prélevés chez des patients présentant des symptômes correspondant à ceux de la cystite interstitielle sont ajoutés au système d'essai. La liaison de l'APF à la protéine 4 associée au cytosquelette (CKAP4) indique de manière positive la présence d'APF dans l'urine et est diagnostiquée pour la cystite interstitielle. Le système diagnostique est une avancée importante et étonnante pour diagnostiquer la cystite interstitielle et possède des applications commerciales qui concernent les hommes et les femmes souffrant de symptômes correspondant à ceux de la cystite interstitielle.

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