Cell constructs cultured in vitro, preparation and uses

Details Cell constructs cultured in vitro, preparation and uses Cell constructs cultured in vitro, preparation and uses

C - Chemistry, Metallurgy

12

N

C12N 5/077 (2010.01) A61K 35/32 (2006.01) A61L 27/38 (2006.01) C12N 11/00 (2006.01) A61K 35/12 (2006.01)

Patent

CA 2469611

The invention concerns a cell construct cultured in vitro characterized in that it comprises: (i) animal cells culturedin vitro in conditions ensuring formation of a three-dimensional tissue structure and (ii) an endogenous extracellular matrix wherein said cells are imprisoned, and it comprises, among said cells, cells having mineral- and/or bone-forming property. The invention is particularly useful in the field of grafts and implantology (tissue reconstruction or repair), as well as in the pharmaceutical industry, for research on tissue and analysis of the toxic or beneficial profile of molecules capable of being used in pharmaceutics development and/or pharmaceutical compositions.

La présente invention concerne un construit cellulaire cultivé in vitro caractérisé en ce qu'il comprend (i) des cellules animales cultivées in vitro dans des conditions assurant la formation d'une structure tissulaire tridimensionnelle et (ii) une matrice extra-cellulaire endogène dans laquelle lesdites cellules sont emprisonnées, et en ce qu'il comprend, parmi lesdites cellules, des cellules ayant une capacité de minéralisation et/ou d'ossification. L'invention est particulièrement utile dans le domaine des greffes ou de l'implantologie (reconstitution ou réparation tissulaire), ainsi que dans l'industrie pharmaceutique, pour l'étude des tissus et l'analyse du profil toxique ou bénéfique de molécules susceptibles d'entrer en développement pharmaceutique et/ou dans des compositions pharmaceutiques.

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