Cell-culture and polymer constructs

Details Cell-culture and polymer constructs Cell-culture and polymer constructs

C - Chemistry, Metallurgy

12

N

C12N 5/08 (2006.01) A61F 2/08 (2006.01) A61L 27/20 (2006.01) A61L 27/38 (2006.01) C08B 15/00 (2006.01) C08B 37/00 (2006.01) C08B 37/02 (2006.01) C12N 5/00 (2006.01) C12N 5/06 (2006.01) C12P 21/06 (2006.01) A61K 35/12 (2006.01)

Patent

CA 2366669

Cells grown on a microcarrier are separated from the microcarrier by enzymatically digesting the microcarrier. More specifically, chondrocytes may be grown on dextran microcarrier beadlets and then the beadlets digested using dextranase to separate the chondrocytes from the carrier. Cells can also be grown on chitosan microcarriers to be used for implantation. In addition, cells can be grown on polysaccharide polymers to be used as implant devices. Various polymers serve as scaffolds for cells to be used for implantation. The polymers can be used for cell culture as well as for preparing scaffolds useful for tissue replacement such as cartilage tissue.

Selon cette invention, des cellules mises en culture sur un microsupport sont séparées de ce microsupport par digestion enzymatique de ce dernier. De manière plus spécifique, des chondrocytes peuvent être mis en culture sur des billes microporteuses qui sont ensuite digérées par la dextranase de sorte que ces chondrocytes soient séparés du support. Ces cellules peuvent également être cultivées sur des microsupports de chitosan pour être utilisées en implantation. Divers polymères servent de squelettes pour les cellules devant être utilisées en implantation. Les polymères peuvent être utilisés dans la culture cellulaire ainsi que dans la préparation de squelettes utiles dans le remplacement de tissus tels que des tissus de cartilage.

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