Cell culture system for synthesis of infectious hepatitis c...

Details Cell culture system for synthesis of infectious hepatitis c... Cell culture system for synthesis of infectious hepatitis c...

C - Chemistry, Metallurgy

12

N

C12N 7/00 (2006.01) A61K 45/00 (2006.01) A61P 31/14 (2006.01) C07K 14/18 (2006.01) C12N 1/02 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12Q 1/04 (2006.01) C12Q 1/24 (2006.01) C12Q 1/70 (2006.01) G01N 33/576 (2006.01)

Patent

CA 2440433

The invention relates to a hepatitis C virus (HCV) cDNA-based culture system capable of synthesis of infectious HCV in cell culture and cell-to-cell spread of the virus. The invention also relates to a method of measuring the level of HCV infection in a hepatocyte cell. A method for identifying a modulator of HCV activity is also presented, and a method for modulating HCV activity. The invention provides a reliable system for both genetic analysis of the viral genome and for the development of novel antiviral str ategies.

L'invention concerne une culture à base d'ADNc du virus de l'hépatite C (HCV) capable de réaliser la synthèse de HCV infectieux dans une culture cellulaire et la diffusion intercellulaire du virus. Elle concerne également un procédé servant à mesurer le niveau de l'infection par HCV dans une cellule hépatocyte. Elle concerne également un procédé servant à identifier un modulateur de l'activité de HCV, ainsi qu'un procédé servant à moduler l'activité de HCV. Elle constitue un système fiable à la fois pour l'analyse génétique du génome viral et pour le développement de nouvelles stratégies antivirales.

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