C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/06 (2006.01)
Patent
CA 2667238
The invention relates to a cell culture system, particularly for the preclinical testing of active ingredients, comprising a first and a second compartment. The active ingredients are in communication with each other via a separation layer that is permeable for cellularly secretable substances between the first and second compartments, wherein the first compartment comprises a syntopic culture with tissue cells and immune cells and the second compartment has a culture with blood cells. The invention further relates to a corresponding method and to a kit and uses for the preclinical testing of active ingredients.
L'invention concerne un système de culture cellulaire, en particulier pour l'expérimentation préclinique de substances actives, comprenant un premier et un deuxième compartiment qui sont en communication mutuelle par l'intermédiaire d'une couche séparatrice, disposée entre le premier et le deuxième compartiment et perméable aux substances secrétées par les cellules. Le premier compartiment présente une culture syntopique avec des cellules tissulaires et des cellules immunitaires, et le deuxième compartiment présente une culture de cellules sanguines. L'invention concerne en outre un procédé correspondant ainsi qu'un kit et des utilisations pour l'expérimentation préclinique de substances actives.
Edi (experimentelle & Diagnostische Immunologie) Gmbh
Robic
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