Cell-cycle checkpoint genes

Details Cell-cycle checkpoint genes Cell-cycle checkpoint genes

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) C07K 16/40 (2006.01) C12N 9/12 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2231190

This invention relates to a class of checkpoint genes and their polypeptide products which control progression through the cell cycle in eukaryotic cells. In particular this invention relates to Schizosaccharomyces pombe rad3 gene, to its human homologue (ATR) and to their encoded proteins. The invention further relates to assay methods for selecting compounds which modulate the activity of the polypeptide products of these checkpoint genes and the use of the selected compounds in anticancer therapy.

Cette invention se rapporte à une classe de gènes de point de contrôle et à leurs produits polypeptidiques qui commandent la progression à travers le cycle cellulaire de cellules eukaryotes. Cette invention se rapporte en particulier au gène Schizosaccharomyces pombe rad3, à son homologue humain (ATR) et à leurs protéines codées. Cette invention se rapporte en outre à des procédés d'analyse pour sélectionner des composés qui modulent l'activité des produits polypeptidiques de ces gènes de point de contrôle, ainsi qu'à l'utilisation de ces composés sélectionnés dans des thérapies anticancéreuses.

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