Cell cycle checkpoint pik-related kinase materials and methods

Details Cell cycle checkpoint pik-related kinase materials and methods Cell cycle checkpoint pik-related kinase materials and methods

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) C07K 16/40 (2006.01) C12N 5/20 (2006.01) C12N 9/12 (2006.01) C12N 15/06 (2006.01) C12N 15/07 (2006.01) C12N 15/11 (2006.01) C12N 15/52 (2006.01) C12N 15/79 (2006.01) C12N 15/87 (2006.01) C12Q 1/02 (2006.01) C12Q 1/48 (2006.01) C12Q 1/50 (2006.01)

Patent

CA 2210650

The present invention generally relates to genes encoding cell cycle checkpoint phosphatidylinositol kinase (PIK)-related proteins essential to DNA damage responses in cells. These PIK-related kinases are required in regulatory pathways that arrest the cell cycle following DNA damage to allow DNA repair prior to mitosis or initiation of DNA replication. More particularly, the invention provides a novel human cell cycle checkpoint PIK-related kinase, MCCS1, and polynucleotide sequences encoding the MCSS1. Assays for identifying modulators of MCCS1 useful as, for example, chemotherapy and radiation adjuvants, are also provided by the invention. Further, assays for identifying modulators of the cell cycle checkpoint phosphatidylinositol kinase (PIK)-related protein identified as ATM are provided.

L'invention concerne d'une manière générale des gènes codant des protéines relatives à la phosphatidylinositol kinase (PIK) du point de contrôle du cycle cellulaire, ces protéines étant essentielles aux réponses de dommages de l'ADN dans les cellules. Ces kinases relatives à PIK sont nécessaires dans les chemins régulateurs qui arrêtent le cycle cellulaire suite à des dommages de l'ADN afin de permettre la réparation de l'ADN avant une mitose ou un début de réplication de l'ADN. Plus particulièrement, l'invention concerne une nouvelle kinase relative à PIK du point de contrôle du cycle des cellules humaines, MCCS1, et des séquences polynucléotidiques codant MCSS1. Des dosages permettant d'identifier des modulateurs de MCCS1 utiles par exemple en chimiothérapie et comme adjuvant de radiation sont également décrits dans l'invention. Celle-ci décrit également des dosages permettant d'identifier des modulateurs de la protéine relative à phosphatidylinositol kinase du point de contrôle du cycle cellulaire, lesquels ont reçu l'identification ATM.

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