Cell-cycle regulatory proteins, and uses related thereto

Details Cell-cycle regulatory proteins, and uses related thereto Cell-cycle regulatory proteins, and uses related thereto

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 9/12 (2006.01) C12N 15/85 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2186639

The present invention relates to the discovery in eukaryotic cells, particularly mammalian cells, of a novel family of cell-cycle regulatory proteins ("CCR-proteins"). As described herein, this family of proteins includes a polypeptide having an apparent molecular weight of 16 kDa, and a polypeptide having an apparent molecular weight of approximately 15 kDa, each of which can function as an inhibitor of cell-cyle progression, and therefore ultimately of cell growth. Thus, similar to the role of p21 to the p53 checkpoint, the subject CCR-proteins may function coordinately with the cell-cycle regulatory protein, retinoblastoma (RB). Furthermore, the CCR-protein family includes a protein having an apparent molecular weight of 13.5 kDa (herinafter "p13.5"). The presumptive role of p13.5, like p16 and p15, is in the regulation of the cell-cycle.

L'invention porte sur la découverte de cellules eukaryotes, de mammifères en particulier, d'une nouvelle famille de protéines régulatrices du cycle cellulaire (protéines CCR). Ainsi qu'on le décrit ici, ladite famille comporte un polypeptide d'un poids moléculaire apparent de 16 kDa et un polypeptide d'un poids moléculaire approximatif de 15 kDa pouvant tous deux agir comme inhibiteurs de la progression du cycle cellulaire et donc finalement de la croissance cellulaire. Jouant un rôle similaire à celui des points de contrôle p21 et p 53, lesdites protéines CCR peuvent donc agir en coordination avec la protéine régulatrice du cycle cellulaire, la rétinoblastome (RB). Ladite famille comporte en outre une protéine d'un poids moléculaire apparent de 13,5 kDa, la "p,13,5" qui, comme la p16 et la p15, devrait intervenir dans la régulation du cycle cellulaire.

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