Cell death protein

Details Cell death protein Cell death protein

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 14/715 (2006.01) C07K 16/18 (2006.01) C07K 16/24 (2006.01) C07K 16/40 (2006.01) C12N 9/12 (2006.01) C12N 15/85 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2219984

Disclosed is a protein, designated RIP, which contains a death domain at its carboxy terminus and a kinase domain at its amino terminus. RIP interacts with the Fas/APO-1 intracellular domain and the TNFR1 intracellular domain. When expressed in transformed host cells, recombinant RIP promotes apoptosis. Also disclosed are DNA molecules encoding RIP, anti-RIP antibodies, and screening methods for discovering inhibitors of RIP-dependent apoptosis.

L'invention décrit une protéine, appelée RIP, contenant un domaine mort à son extrémité carboxy et un domaine kinase à son extrémité amino. La RIP interagit avec les domaines intracellulaires Fas/APO-1 et TNFR1. Lorsqu'elle est exprimée dans des cellules hôtes transformées, la RIP de recombinaison favorise l'apoptose. L'invention décrit aussi des molécules d'ADN codant RIP, des anticorps anti-RIP et des procédés de criblage pour découvrir des inhibiteurs de l'apoptose dépendante de RIP.

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