Cell derived antigen presenting vesicles

Details Cell derived antigen presenting vesicles Cell derived antigen presenting vesicles

A - Human Necessities

61

K

A61K 39/385 (2006.01) A61K 39/04 (2006.01) A61K 39/39 (2006.01)

Patent

CA 2225553

The invention provides a novel vehicle for vaccination, in particular peptide vaccination. The new vehicle has been termed an exosome. Exosomes are vesicles derived from MHC class II enriched compartments in antigen presenting cells. The exosomes possess MHC II and/or MHC I molecules at their surface and possibly peptides derived from processed antigens in said MHC's. Thus the exosome is a perfect vaccination vehicle in that it presents the peptide in a natural setting. The peptides present in the exosome in the MHC molecule may be processed by the antigen presenting cell from which the exosome is derived. Empty MHC molecules on exosomes may also be loaded with peptides afterwards.

L'invention porte sur un nouveau véhicule destiné à la vaccination, en particulier la vaccination peptidique. Le nouveau véhicule porte le nom d'exosome. Les exosomes sont obtenus à partir de compartiments enrichis au CMH de classe II se trouvant dans les cellules présentant des antigènes. Les exosomes comportent des molécules de CMH II et/ou des molécules de CMH I en surface et éventuellement des peptides obtenus à partir des antigènes traités dans les CMH précités. L'exosome est donc parfait comme véhicule de vaccination car il présente le peptide dans un environnement naturel. Les peptides présents dans l'exosome de la molécule de CMH peuvent être traités par la cellule présentant des antigènes dont est dérivé l'exosome. Les molécules de CMH vides se trouvant sur les exosomes peuvent également être chargées de peptides ultérieurement.

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