C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 1/38 (2006.01) C07K 14/475 (2006.01) C07K 14/78 (2006.01) C12N 5/06 (2006.01) C12N 5/16 (2006.01) C12N 5/22 (2006.01) C12N 15/87 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2324591
The present invention relates to a biologically active factor capable of influencing differentiation, proliferation and/or maintenance of pluripotent cells. The present invention also relates to methods of using the biologically active factor to produce from pluripotent cells, pluripotent cells having different properties, more particularly EPL cells; and to methods of producing partially or terminally differentiated cells from the pluripotent cells. The present invention also relates to pluripotent cells and partially or terminally differentiated cells, and their uses in human cell and gene therapy, and transgenic animal production.
La présente invention concerne un facteur biologiquement actif capable d'influer sur la différentiation, la prolifération et/ou la conservation des cellules multipotentes. L'invention se rapporte également à des procédés d'utilisation du facteur biologiquement actif visant à produire des cellules multipotentes, des cellules multipotentes possédant des propriétés différentes et plus particulièrement des cellules précoces du type d'ectoderme primaire (cellules EPL). L'invention concerne aussi des cellules multipotentes et des cellules partiellement ou définitivement différenciées ainsi que leur utilisation en thérapie génique et dans celle des cellules humaines ainsi que dans la fabrication d'animaux transgéniques.
Bettess Michael David
Lake Julie-Anne
Rathjen Joy
Rathjen Peter David
Washington Jennifer
Bresagen Inc.
Bresagen Limited
Sim & Mcburney
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