Cell-driven viral transfer in eukaryotes

Details Cell-driven viral transfer in eukaryotes Cell-driven viral transfer in eukaryotes

C - Chemistry, Metallurgy

12

N

167/139, 195/46,

C12N 5/02 (2006.01) C07K 16/00 (2006.01) C12N 15/00 (2006.01)

Patent

CA 1187010

17 CELL-DRIVEN VIRAL TRANSFER IN EUKARYOTES ABSTRACT OF THE DISCLOSURE Novel method, cells and compositions are provided involving transforming B-lymphocytes to provide immortali- zation for continuous production of monoclonal antibodies to a predetermined ligand. T-cell free B-lymphocytes are combined with an Epstein-Barr virus transformed cell sen- sitive to a cytotoxic agent which does not significantly affect the B-lymphocytes under conditions where the sen- sitive EBV transformed cell acting as the transfer agent is killed and efficiently transforms the B-lymphocyte recipient cells with EBV. The EBV transformed B-lymphocyte cells are amplified and cloned, the desired clones isolated in accordance with conventional techniques and then used for production of monoclonal antibodies.

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