Cell excluding sheath for vascular grafts

A - Human Necessities – 61 – L

Patent

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Details

A61L 27/00 (2006.01) A61F 2/06 (2006.01) A61L 27/16 (2006.01) A61L 27/34 (2006.01)

Patent

CA 2186373

The present invention is directed to a sheath for use with vascular prostheses derived from donor blood vessels, particularly mam- malian blood vessels. A vascular prosthesis of the present invention employs an external sheath around a donor blood vessel. The sheath pre- vents access to the donor vessel wall by host cells originating from perigraft tissue. While re- sistant to host cell ingrowth, the external sheath is permeable to the flux of macromolecules across its thickness. The exclusion of host cells by the external sheath and the bi-directional flow of macromolecules through the external sheath assists in maintaining the original function of the underlying donor vascular tissue of the prosthe- sis.

Enveloppe destinée à être utilisée avec des prothèses vasculaires provenant de vaisseaux sanguins prélevés sur un donneur, et notamment de vaisseaux sanguins de mammifère. Une prothèse vasculaire de cette invention utilise une enveloppe extérieure placée autour du vaisseau sanguin donné. Cette enveloppe empêche les cellules hôtes issues des tissus entourant la greffe d'accéder à la paroi du vaisseau donné, elle ne laisse pas passer les cellules hôtes mais est cependant perméable au flux de macromolécules qui peuvent traverser son épaisseur. L'exclusion des cellules hôtes par l'enveloppe extérieure et l'écoulement bidirectionnel des macromolécules à travers son épaisseur aident à maintenir la fonction originelle des tissus vasculaires donnés sous-jacents de la prothèse.

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