Cell growth substrate polymer

Details Cell growth substrate polymer Cell growth substrate polymer

C - Chemistry, Metallurgy

08

F

C08F 290/06 (2006.01) A61F 2/14 (2006.01) A61K 35/12 (2006.01) A61L 27/00 (2006.01) A61L 27/18 (2006.01) A61L 31/00 (2006.01) C07K 17/08 (2006.01) C08G 18/50 (2006.01) C08G 18/81 (2006.01) C12M 3/00 (2006.01) C12N 5/00 (2006.01) C12N 11/08 (2006.01) G02B 21/34 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2215138

Cell growth substrate polymers are described which comprise a macromonomer of the formula (I): Q -(PFPE - L)n-1 -PFPE-Q, wherein n is at least 1.0; each PFPE may be the same or different and is a perfluorinated polyether of the formula (II): -OCH2CF2O (CF2CF2O)x(CF2O)y CF2CH2O-, wherein the CF2CF2O and CF2O units may be randomly distributed or distributed as blocks throughout the chain and wherein x and y may be the same or different such that the molecular weight of the perfluoropolyether is in the range of from 242 to 4000, L is a difunctional linking group; and Q at each end of the macromonomer is the same or different and is a polymerizable group. The cell growth substrate polymers may be used in the production of corneal implants.

Polymères pour substrats de culture de cellules consistant en un macromonomère de la formule (I): Q-(PFPE -L)n-1 -PFPE-Q dans laquelle: n est au moins 1; les PFPE, qui peuvent être identiques ou différent, consistent en un polyéther perfluoré de la formule (II): -OCH2CF2O (CF2CF2O)x(CF2O)y CF2CH2O- dans laquelle CF2CF2O et CF2O peuvent être distribués aléatoirement ou sous forme de blocs dans la chaîne et où x et y peuvent être identiques ou différents, de manière à ce que le poids moléculaire reste compris entre 242 et 4000; L est un groupe de liaison bifonctionnel; et les Q des deux extrémités du macromonomère qui peuvent être identiques ou différents consistent en groupes polymérisables. Le susdit substrat peut servir à fabriquer des implants cornéens.

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