Cell internalized peptide-drug conjugates

Details Cell internalized peptide-drug conjugates Cell internalized peptide-drug conjugates

A - Human Necessities

61

K

A61K 38/03 (2006.01) A61K 47/48 (2006.01) C07K 2/00 (2006.01) C07K 19/00 (2006.01)

Patent

CA 2417885

Peptides which bind to leukocytes are conjugated with drugs. Advantageously, the peptide-drug conjugates interfere with ICAM-1/LFA-1 interactions and are internalized by leukocytes, whereby the drug portion of the conjugate exerts potent toxic side effects against targeted cells with minimal adverse side effects. Preferred conjugates include 4-30 mer peptides derived from ICAM-1 or LFA-1 coupled with drugs effective against leukocyte-related diseases.

Des peptides se fixant à des leucocytes sont conjugués à des médicaments. Ces conjugués peptides-médicaments jouent un rôle dans les interactions ICAM-1/LFA-1 et sont intégrés par les leucocytes, ce qui permet à la partie médicament du conjugué d'exercer des effets secondaires toxiques puissants contre des cellules ciblées, tout en minimisant les effets secondaires négatifs. Les conjugués préférés comprennent des peptides 4-30 mer dérivés de ICAM-1 ou LFA-1 couplés à des médicaments efficaces contre des maladies apparentées aux leucocytes.

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