Cell-killing molecules and methods of use thereof

Details Cell-killing molecules and methods of use thereof Cell-killing molecules and methods of use thereof

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 38/46 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2514841

The invention provides compositions comprising amino acid sequences that have cell killing activity, nucleic acid sequences encoding them, antibodies that specifically bind with them, and methods of using these compositions for increasing and/or reducing cell death, detecting cell death, diagnosing diseases associated with altered cell death, and methods for identifying test agents that alter cell death.

L'invention concerne des compositions qui comprennent des séquences d'acides aminés présentant une activité d'élimination de cellules, des séquences d'acides nucléiques les codant, des anticorps se liant de manière spécifique à celles-ci; ainsi que des méthodes d'utilisation desdites compositions destinées à augmenter et/ou à réduire la mort cellulaire, à détecter la mort cellulaire, à diagnostiquer des maladies associées à la mort cellulaire altérée, et des méthodes d'identification d'agents de test qui altèrent la mort cellulaire.

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