C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/071 (2010.01) C12N 7/00 (2006.01) C12Q 1/70 (2006.01)
Patent
CA 2216630
The description relates to a permanent cell line derived from a vero-M cell line. This cell line makes it possible to multiply rabies viruses with a cytopathogenic effect (CPE) and detect them sensitively by means of the CPE. Besides processes for multiplying and detecting rabies viruses by means of this cell line, the invention also relates to a process for detecting inhibitors of rabies virus multiplication, like neutralising antibodies or ligands against virus receptors, for example.
L'invention a pour objet une lignée cellulaire permanente dérivée d'un lignée cellulaire vero-M. Cette lignée cellulaire permet à la fois, de réaliser la multiplication de virus de la rage avec un effet cytopathogène (CPE) et de les détecter de manière sensible au moyen du CPE. En plus des procédés de multiplication et de détection des virus de la rage faisant appel à l'utilisation de cette lignée cellulaire, l'invention concerne un procédé de détection d'inhibiteurs de la multiplication des virus de la rage, par exemple d'anticorps neutralisants ou de ligands dirigés contre les récepteurs de virus.
Bernhardt Dieter
Groner Albrecht
Behringwerke Aktiengesellschaft
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Csl Behring Gmbh
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