C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
195/33, 167/37,
C12Q 1/70 (2006.01) C07K 14/16 (2006.01) C12N 5/02 (2006.01) C12N 7/04 (2006.01) C12N 15/01 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1286619
ABSTRACT OF THE DISCLOSURE Leu-3- cells surviving infection with the AIDS retrovirus can be induced with IUdR to express infectious virus. A cellular clone (8E5), isolated by limiting dilution of a mass culture of survivor cells, was found to contain a single, integrated, defective provirus that was constitutively expressed. Although IUdR treatment of 8E5 cells failed to induce infectious virus, cocultiva- tion with Leu-3+ cells generated the characteristic syncytia associated with acute AIDS retrovirus infec- tion. The single integrated copy of proviral DNA directs the synthesis of all major viral structural proteins except p64 and p34 as monitored by immunoblotting. Diag- nostic reagents and kits in accordance with the present invention are also described.
533899
Folks Thomas M.
Martin Malcolm A.
Powell Douglas M.
Gowling Lafleur Henderson Llp
U.s. Departm Ent Of Commerce The United States Of America Represented By The Secretary
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