A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A01K 67/027 (2006.01) A61K 31/7105 (2006.01) A61P 31/12 (2006.01) A61P 31/18 (2006.01) C12N 5/00 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01)
Patent
CA 2506619
Host nucleic acids and host proteins that participate in viral infection, such as human immunodeficiency virus (HIV), influenza A, and Ebola virus, have been identified. Interfering with or disrupting the interaction between a host nucleic acid or host protein and a virus or viral protein confers an inhibition of or resistance to infection. Thus, interfering with such an interaction in a host subject can confer a therapeutic or prophylactic effect against a virus. The sequences identified can be used to identify agents that reduce or inhibit viral infection.
La présente invention concerne l'identification d'acides nucléiques hôtes et de protéines hôtes qui participent à une infection virale, tels que le virus d'immunodéficience humaine (VIH), la grippe A et le virus Ebola. Selon cette invention, le fait d'interférer avec ou d'interrompre l'interaction entre un acide nucléique hôte ou une protéine hôte et un virus ou une protéine virale induit une inhibition ou une résistance à une infection, ce qui peut avoir un effet thérapeutique ou prophylactique contre un virus chez un sujet hôte. Les séquences identifiées peuvent être utilisées afin d'identifier des agents qui réduisent ou inhibent une infection virale.
Hodge Thomas W.
Mcdonald Natalie Jean
Rubin Donald H.
Sanchez Anthony
Shaw Michael W.
Smart & Biggar
The Government Of The United States Of America As Represented By Centers For Disea
Vanderbilt University
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