Cell lines expressing a mch receptor

Details Cell lines expressing a mch receptor Cell lines expressing a mch receptor

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) C12N 5/06 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01) C12N 15/86 (2006.01) C12Q 1/02 (2006.01) G01N 33/74 (2006.01)

Patent

CA 2427763

The present invention features neuroblastoma and skin cell carcinoma cell lines functionally expressing MCHR1 and the use of such cells to measure MCHR1 activity. Functional expression is preferably achieved in a neuroblastoma or skin cell carcinoma using a recombinant gene expressing MCHR1. The presence of a recombinant MCHR1 gene increases the level of MCHR1 expression facilitating the production and detection of MCHR1 activity.

L'invention concerne des lignées cellulaires de neuroblastome et de carcinome de la peau, lesquelles expriment MCHR1; elle concerne également l'utilisation de telles cellules pour mesurer l'activité de MCHR1. L'expression fonctionnelle s'effectue, de préférence, dans un neuroblastome ou dans un carcinome de la peau, à l'aide d'un gène recombinant exprimant MCHR1. La présence d'un gène MCHR1 recombinant augmente le niveau d'expression de MCHR1, facilitant ainsi la production et la détection de l'activité de MCHR1.

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