Cell lines that produce prostaglandin f2 alpha (pgf2a) and...

Details Cell lines that produce prostaglandin f2 alpha (pgf2a) and... Cell lines that produce prostaglandin f2 alpha (pgf2a) and...

C - Chemistry, Metallurgy

12

N

C12N 15/53 (2006.01) A61K 9/00 (2006.01) A61K 31/5575 (2006.01) A61K 35/44 (2006.01) A61L 27/38 (2006.01) C12N 5/10 (2006.01) C12N 9/02 (2006.01) C12N 11/04 (2006.01) C12N 15/85 (2006.01) C12P 31/00 (2006.01)

Patent

CA 2759244

Cells and cell lines that are genetically modified to express the hCox-2 enzyme, which results in the upregulation of prostaglandin F2 alpha (PGF2a) on the cells have been obtained. Encapsulated cell therapy devices containing such cells or cell lines that are capable of delivering PGF2a, as well as methods of using these devices to deliver PGF2a to the eye and to treat ophthalmic disorders in patients suffering therefrom are also described.

L'invention porte sur des cellules et des lignées cellulaires qui sont génétiquement modifiées pour exprimer l'enzyme hCox-2, ce qui conduit à la régulation positive de la prostaglandine F2 alpha (PGF2a) sur les cellules. Elle porte aussi sur des dispositifs de thérapie par cellules encapsulées, contenant les cellules ou lignées cellulaires qui sont capables de libérer la PGF2a, ainsi que sur des procédés d'utilisation de ces dispositifs pour administrer la PGF2a dans l'il et pour traiter des troubles ophtalmiques chez les patients qui en souffrent.

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