Cell membrane-directed drugs

Details Cell membrane-directed drugs Cell membrane-directed drugs

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 47/48 (2006.01) C07K 14/705 (2006.01) C07K 14/745 (2006.01) C07K 14/755 (2006.01) C07K 14/81 (2006.01) C12N 9/64 (2006.01) C12N 15/12 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2276091

Drugs wherein peptides having an affinity specific to phospholipids, preferably those which constitute a lipid bilayer forming a cell cortex and the content of which in the lipid bilayer increases in abnormal cells, for example, injured, denatured or activated cells are bonded to physiologically active substances; deoxyribonucleic acids (DNA) encoding the amino acid sequences of the drugs when the physiologically active substances are peptides; and processes for producing these drugs. These drugs and novel peptides are useful as preventives and remedies for diseases accompanied by blood coagulation disorders, inflammation and immune responses.

Médicaments dans lesquels des peptides présentant une affinité spécifique pour les phospholipides, de préférence, ceux qui constituent une double couche lipidique formant un cortex cellulaire et dont la teneur dans la double couche lipidique augmente dans les cellules anormales, par exemple, des cellules détériorées, dénaturées ou activées, sont liés à des substances actives sur le plan physiologique; acides désoxyribonucléiques (AND) codant les séquences aminoacides de ces médicaments quand les substances actives sur le plan physiologique sont des peptides; procédés servant à préparer ces médicaments. Ces médicaments et ces nouveaux peptides sont utiles afin de prévenir et de traiter des maladies accompagnées par des troubles de coagulation sanguine, de l'inflammation et des réactions immunes.

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