Cell membrane glycoprotein correlated with resistance to...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 14/705 (2006.01) C07H 21/00 (2006.01) C07K 16/28 (2006.01) C12N 1/21 (2006.01) C12N 15/12 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2045231

Abstract of the Disclosure A novel plasma membrane glycoprotein having an approximate molecular weight of 200 kDa has been isolated. The glycoprotein is correlated with CDDP-resistance in murine thymic lymphoma cell sublines from which it was isolated. The glycoprotein, designated CPR-200, appears to be correlated with resistance to the platinum family of anti-neoplastic drugs across species.

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