A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01)
Patent
CA 2607701
A pharmaceutically acceptable composition and method for entering a cell nucleus utilizes a cell nucleus-entering polypeptide including at least one of amino acid sequence LKKTET, amino acid sequence LKKTNT or amino acid sequence KSKLKK, or a conservative variant thereof, linked to a physiologically active agent having at least one of therapeutic or diagnostic application in the cell nucleus.
L'invention concerne une composition pharmaceutiquement acceptable et un procédé pour pénétrer dans le noyau d'une cellule; ils utilisent un polypeptide de pénétration dans le noyau de la cellule qui comprend au moins une séquence d'acide aminé LKKTET, une séquence d'acide aminé LKKTNT ou une séquence d'acide aminé KSKLKK, ou leur variante conservatrice, liés à un agent physiologiquement actif possédant au moins une application thérapeutique ou diagnostique dans le noyau de la cellule.
Crockford David
Goldstein Allan L.
Hannappel Ewald
Huff Thomas
Friedrich-Alexander-Universitaet Erlangen-Nuernberg
Norton Rose Or S.e.n.c.r.l.,s.r.l./llp
Regenerx Biopharmaceuticals Inc.
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