Cell penetrating peptide conjugates for delivering of...

Details Cell penetrating peptide conjugates for delivering of... Cell penetrating peptide conjugates for delivering of...

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 31/74 (2006.01) C08G 65/329 (2006.01)

Patent

CA 2633063

The invention provides cell penetrating peptide-nucleic acid conjugates having the formula P- L-N, wherein P is a cell penetrating peptide, N is a nucleic acid, preferably an oligonucleotide and more preferably a siRNA, and L is a hydrophilic polymer, preferably a polyethylene glycol (PEG)-based linker linking P and N together. Compositions, methods of use and methods for producing such conjugates are also disclosed.

L'invention concerne des conjugués peptide/acide nucléique pour la pénétration cellulaire, de formule P-L-N, où P est un peptide de pénétration cellulaire, N est un acide nucléique, de préférence un oligonucléotide et de façon plus préférentielle un ARNsi, et L est un polymère hydrophile, de préférence un segment de liaison à base de polyéthylène glycol (PEG) qui relie P et N entre eux. L'invention concerne en outre des compositions, des méthodes d'utilisation et des procédés de production de ces conjugués.

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