A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/12 (2006.01) C07K 14/025 (2006.01) C12N 15/62 (2006.01)
Patent
CA 2694735
The present invention relates to use of a new cell penetrating peptides (CPP) and in particular to the region 32-51 of protein Limulus antilipopolisacarido (LALF) and its analogous. This invention refers to compositions containing these peptides associated to biomolecules with therapeutics properties. This invention consist of compositions comprise the covalent fusion of biomolecules, between this human papillomavirus antigens (HPV) to these CPP for induce a potent immune cellular responses against HPV and HPV protein antigen- exhibiting cells including HPV-associated tumors. The referred compositions are applicable in the pharmaceutical industry as vaccine for therapeutic use in human.
La presente invención se refiere al uso de nuevos péptidos penetradores a células (PPC) y en particular a la región 32-51 de la proteína Limulus antilipopolisacárido (LALF) y sus análogos. Esta invención se refiere a composiciones que contienen estos péptidos asociados a biomoléculas con propiedades terapéuticas. Esta invención consiste en composiciones que contienen la fusión covalente de biomoléculas, entre ellas antígenos del virus de papiloma humano (VPH), a estos PPC, para inducir una potente respuesta inmune celular contra el VPH y contra células que expongan antígenos del VPH incluyendo tumores asociados al VPH. Las composiciones referidas son aplicables en la industria farmacéutica como vacunas para uso terapéutico en humano.
Acevedo Castro Boris Ernesto
Granadillo Rodriguez Milaid
Guerra Vallespi Maribel
Madrazo Isis Del Carmen Torrens
Reyes Acosta Osvaldo
Centro de Ingenieria Genetica Y. Biotecnologia
Deeth Williams Wall Llp
LandOfFree
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