C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 38/10 (2006.01) C07K 7/08 (2006.01) C07K 14/00 (2006.01) C07K 14/47 (2006.01) C07K 19/00 (2006.01)
Patent
CA 2471762
The invention provides cell-permeable peptides that selectively block the branch of the JNK signaling pathway controlled by the islet-brain (IB) proteins. The provided cell-permeable peptides block the binding of intermediate kinases in the c-Jun amino terminal kinase (JNK) signaling pathway, thereby decreasing the downstream effects of c-Jun amino terminal kinase (JNK).
L'invention concerne des peptides à perméabilité cellulaire qui bloquent sélectivement la voie du processus de signalisation JNK au moyen des protéines des cellules des îlots de Langerhans (IB). Ces peptides à perméabilité cellulaire bloquent la liaison des kinases intermédiaires dans le processus de signalisation de la kinase c-Jun amino-terminal (JNK), ce qui permet de diminuer les effets en aval de la kinase c-Jun amino-terminal (JNK).
Ridout & Maybee Llp
University Of Lausanne
Xigen Sa
LandOfFree
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