Cell populations which co-express cd49c and cd90

Details Cell populations which co-express cd49c and cd90 Cell populations which co-express cd49c and cd90

C - Chemistry, Metallurgy

12

N

C12N 5/078 (2010.01) C12N 5/071 (2010.01) C12N 5/074 (2010.01) A61K 35/28 (2006.01) A61K 35/12 (2006.01)

Patent

CA 2461068

Substantially homogenous cells populations which co-express CD49c, CD90 and telomerase are made. In one embodiment, humans suffering from a degenerative, traumatic, acute injury, cardiac or neurological condition are treated with the substantially homogenous cells populations which co-express CD49c, CD90 and telomerase. In another embodiment, committed progenitor cells are made are made by selecting from a cultured source of a cell populations which co- express CD49c and CD90 and modifying the cell population. The committed progenitor cells can be employed to treat a human suffering from a degenerative, traumatic, acute injury, cardiac or neurological condition and to formulate pharmaceutical compositions. In a further embodiment, a substantially homogenous populaton of cells which co-express CD49c, CD90 and at least one cardiac-related transcription factor is made and can be used to treat a human suffering from a cardiac condition.

L'invention concerne l'élaboration de populations cellulaires pratiquement homogènes qui co-expriment CD49c, CD90 et la télomérase. Un mode de réalisation a trait à au traitement d'êtres humains souffrant d'un accident grave, traumatique, dégénératif, d'une affection cardiaque ou neurologique, au moyen de populations cellulaires pratiquement homogènes qui co-expriment CD49c, CD90 et la télomérase. Dans un autre mode de réalisation, on élabore des précurseurs déterminés en les sélectionnant à partir d'une source cultivée d'une population cellulaire qui co-exprime CD49c et CD90 et en modifiant la population cellulaire. On peut utiliser les précurseurs déterminés, afin de traiter un être humain souffrant d'un accident grave, traumatique, dégénératif, d'une affection cardiaque ou neurologique et, afin de préparer des compositions pharmaceutiques. Dans un autre mode de réalisation, on élabore une population cellulaire pratiquement homogène qui co-exprime CD49c, CD90 et au moins un facteur de transcription cardiaque et on peut utiliser cette population pour traiter un être humain souffrant d'une affection cardiaque.

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