Cell-seeded extracellular matrix grafts

Details Cell-seeded extracellular matrix grafts Cell-seeded extracellular matrix grafts

A - Human Necessities

61

L

A61L 27/38 (2006.01) A61F 2/02 (2006.01) A61L 27/50 (2006.01) A61L 27/60 (2006.01)

Patent

CA 2484614

Described are tissue graft constructs that include an extracellular matrix material in combination with added endothelial cells and at least one additional added exogenous cellular population. The additional exogenous cellular population desirably includes muscle cells, such as smooth muscle cells, fibroblasts, or a combination thereof. Tubular constructs seeded with such cell combinations can be beneficially used as vascular grafts. Also described are methods for preparing and using such grafts.

La présente invention concerne des construits de greffe de tissu qui comprennent un matériau de matrice extracellulaire en combinaison avec des cellules endothéliales ajoutées et avec au moins une population cellulaire exogène ajoutée. Il est souhaitable que la population cellulaire exogène additionnelle comprenne des cellules musculaires, telles que des cellules de muscle lisse, des fibroblastes ou une combinaisons de ceux-ci. Des construits tubulaires ensemencés avec ces combinaisons de cellules peuvent être utilisés avec profit comme greffons vasculaires. Cette invention concerne aussi des techniques de préparation et d'utilisation de ces greffons.

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