C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/38 (2006.01) A61K 48/00 (2006.01) C07K 14/035 (2006.01) C12N 7/00 (2006.01) C12N 7/04 (2006.01) C12N 15/86 (2006.01) C12N 15/869 (2006.01)
Patent
CA 2383372
The present invention relates to herpes viral mutants and methods of using these viral mutants for selectively targeting tumor cells or other populations of target cells. The viral mutants of the invention are capable of selective targeting due to the use of tumor-specific and/or cell-specific promoters to drive expression of the herpes .gamma.34.5 gene.
La présente invention concerne des mutants viraux de l'herpès viral et des procédés d'utilisation de ces mutants viraux dans le ciblage sélectif des cellules tumorales ou d'autres populations de cellules cibles. Les mutants viraux de cette invention sont capables de ciblage sélectif, en raison de l'utilisation de promoteurs spécifiques de cellules et/ou de tumeur pour conduire l'expression du gène .gamma.34.5 de l'herpès.
Chiocca E. Antonio
Chung Richard Y.
Gowling Lafleur Henderson Llp
The General Hospital Corporation
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