Cell specific cytotoxic agents derived from diphtheria toxin

Details Cell specific cytotoxic agents derived from diphtheria toxin Cell specific cytotoxic agents derived from diphtheria toxin

C - Chemistry, Metallurgy

07

K

530/13, 530/7.1,

C07K 14/34 (2006.01) A01N 63/02 (2006.01) A61K 47/48 (2006.01) C07K 19/00 (2006.01)

Patent

CA 1340612

This invention relates to a modified diphtheria toxin (DT) and method of preparing the same in which two carboxy-terminal truncated forms of DT are prepared by specific chemical proteolysis generating two new proteins HA51DT and HA48DT which can be chemically linked to a cell specific binding moiety to produce potent cytotoxins. This invention further relates to carboxy terminal peptides formed in accordance with said proteolysis generating three peptides HA11DT, HA7DT and HA3DT.

593101

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