C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/47 (2006.01) C12N 15/63 (2006.01) C12Q 1/02 (2006.01) C12Q 1/66 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2341051
The present invention is in the field of the gene promoters which mediate the transcription of proteins which play a part in the energy management of cells and in obesity. The invention relates to DNA molecules which contain recombinant cell-specific promoters of uncoupling protein 3 (UCP 3) or functional derivatives thereof. It also relates to cells which contain these DNA molecules. The invention also relates to uses of these DNA molecules and the cells according to the invention, and processes for finding substances which are capable of influencing transcription. These processes can also be carried out by the High Throughput Screening method. Processes are also disclosed which can be used to find substances or factors which bind to the DNA molecules according to the invention.
L'invention a trait au domaine des promoteurs géniques induisant la transcription de protéines intervenant dans la gestion de l'énergie par les cellules et sur l'obésité. Elle porte sur des molécules d'ADN contenant des promoteurs spécifiques des cellules de recombinaison de la protéine brûleuse de graisses excédentaires (UCP 3) ou ses dérivés fonctionnels, sur des cellules contenant ces molécules d'ADN, sur un procédé de recherche de substances susceptibles d'agir sur la transcription pouvant également s'effectuer par criblage à grand rendement, et sur des procédés de recherche de substances ou de facteurs se fixant à des molécules d'ADN en conformité avec l'invention.
Esterbauer Harald
Oberkofler Hannes
Patsch Wolfgang
Boehringer Ingelheim International Gmbh
Fetherstonhaugh & Co.
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