Cell specific replication-competent viral vectors comprising...

Details Cell specific replication-competent viral vectors comprising... Cell specific replication-competent viral vectors comprising...

C - Chemistry, Metallurgy

12

N

C12N 15/861 (2006.01) A61K 48/00 (2006.01) C12N 5/10 (2006.01) C12N 7/01 (2006.01) C12N 15/34 (2006.01)

Patent

CA 2525401

Cell specific replication-competent viral vectors comprising a self processing peptide cleavage sequence are provided. The targeted replication-competent viral vectors include two or more co-transcribed genes under transcriptional control of the same heterologous transcriptional regulatory element (TRE), wherein at least a second gene is under translational control of a self processing cleavage sequence or 2A sequence. Exemplary vector constructs may further include an additional proteolytic cleavage site which provides a means to remove the self processing peptide sequence from the viral vector.

L'invention concerne des vecteurs viraux à capacité de réplication spécifique des cellules, comprenant une séquence de clivage peptidique à auto-traitement. Ces vecteurs viraux à capacité de réplication ciblée comprennent au moins deux gènes co-transcrits sous contrôle transcriptionnel du même élément de régulation de transcription hétérologue (TRE), au moins un second gène étant sous contrôle de la traduction d'une séquence de clivage à auto-traitement ou d'une séquence 2A. Des exemples de vecteurs hybrides peuvent également comprendre un site de clivage protéolytique supplémentaire founissant un moyen pour enlever la séquence peptidique à auto-traitement du vecteur viral.

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