C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 39/395 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 1/21 (2006.01) C12N 15/62 (2006.01) C12N 15/67 (2006.01) C12P 21/08 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2096975
The present invention relates to DNA sequence coding for part or all of the heat shock transcription factor or heat shock factor (HSF) proteins derived from humans and Drosophila, and the proteins encoded by these sequences. The present invention also includes methods for detecting HSF in a biological sample. The presence of HSF in the nucleus of a colt can be detected with specific anti-HSF antibody reagents. The presence of such HSF proteins in the nucleus indicates a stressed condition including diseases. Furthermore, the presence of multimeric HSF in the crude ar fractionated cell extract is indicative of a stressed state.
Clos Joachim
Rabindran Sridhar
Westwood Timothy J.
Wu Carl
Sim & Mcburney
The Government Of The United States Of America
U.s. Departm Ent Of Commerce The United States Of America Represented By The Secretary
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