Cell-surface decoration with active agents

Details Cell-surface decoration with active agents Cell-surface decoration with active agents

A - Human Necessities

61

K

A61K 47/24 (2006.01) C12N 5/071 (2010.01) A61K 9/127 (2006.01) A61K 9/19 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2605863

A lipid vesicle comprising a functionalized lipid comprising a tether moiety having binding affinity for a ligand portion of an active agent and the active agent are provided. Methods of decorating endothelial cells, tissues, and organs with active agents utilizing the disclosed lipid vesicles are also provided.

La présente invention concerne une vésicule lipide comprenant un lipide fonctionnalisé comprenant une fraction d'attache présentant une affinité de liaison pour une partie ligand d'un agent actif et concerne également l'agent actif. Cette invention concerne également des procédés permettant de décorer des cellules endothéliales, des tissus et des organes avec ces agents actifs à l'aide des vésicules lipides susmentionnées.

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