C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 5/16 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2282727
Novel cell surface molecules recognized by monoclonal antibodies against a cell surface molecule of lymphocytic cells that play an important role in autoimmune diseases and allergic diseases have been isolated, identified, and analyzed for their functions. The cell surface molecules are expressed specifically in thymocytes, lymphocytes activated by ConA-stimulation, and peripheral blood lymphocytes, and induce cell adhesion. Antibodies against the cell surface molecules significantly ameliorate pathological conditions of autoimmune diseases and allergic diseases.
On a isolé et identifié une nouvelle molécule de surface cellulaire reconnue par un anticorps monoclonal, laquelle est exprimée spécifiquement dans des thymocytes, des lymphocytes activés par stimulation de la concanavalline A et des lymphocytes du sang périphérique, et a été découverte parmi des anticorps monoclonaux contre des molécules de surface cellulaire dans des cellules lymphocytaires jouant des rôles importants dans des maladies autoimmunes et des maladies allergiques. De plus, on a analysé des fonctions de cette molécule. En outre, on a découvert qu'un anticorps contre cette molécule améliore de manière significative les états pathologiques dus à des maladies autoimmunes et des maladies allergiques.
Tamatani Takuya
Tezuka Katsunari
Blake Cassels & Graydon Llp
Japan Tobacco Inc.
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