Cell surface receptor isoforms and methods of identifying...

Details Cell surface receptor isoforms and methods of identifying... Cell surface receptor isoforms and methods of identifying...

C - Chemistry, Metallurgy

07

K

C07K 14/705 (2006.01)

Patent

CA 2565974

Isoforms of cell surface receptors, including isoforms of receptor tyrosine kinases and pharmaceutical compositions containing receptor tyrosine kinase isoforms are provided. Chimeras of and conjugates containing the cell surface receptors that contain a portion, such as or a part thereof of an extracellular domain, from one cell surface receptor and a second portion, particularly an intron-encoded portion, from a second cell surface protein also are provided. The isoforms modulate the activity of a cell surface receptor. Methods for identifying and preparing isoforms of cell surface receptors including receptor tyrosine kinases are provided. Also provided are methods of treatment with the cell surface receptor isoforms.

L'invention concerne des isoformes de récepteurs de la surface cellulaire, comprenant des isoformes des tyrosine kinases réceptrices ainsi que des compositions pharmaceutiques contenant des isoformes des tytosine kinases réceptrices. L'invention concerne également des chimères et des conjugués contenant les récepteurs de la surface cellulaire qui contiennent une partie, tel qu'un élément associé d'un domaine extracellulaire, d'un récepteur de la surface cellulaire et une seconde partie, en particulier, une partie codée par un intron, d'une seconde protéine de la surface cellulaire. Lesdits isoformes modulent l'activité d'un récepteur de la surface cellulaire. L'invention concerne en outre des méthodes d'identification et de préparation d'isoformes de récepteurs de la surface cellulaire comprenant des tyrosines kinases réceptrices. L'invention concerne enfin des méthodes de traitement faisant appel aux isoformes de récepteurs de la surface cellulaire.

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