Cell surface receptors homologous to coagulation factors v...

Details Cell surface receptors homologous to coagulation factors v... Cell surface receptors homologous to coagulation factors v...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 39/395 (2006.01) C07K 14/575 (2006.01) C07K 14/705 (2006.01) C07K 14/745 (2006.01) C07K 14/755 (2006.01) C07K 16/28 (2006.01) C07K 16/36 (2006.01) C12N 15/57 (2006.01) G01N 33/566 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2105993

2105993 9216558 PCTABS00016 A new class of cellular receptors extensively homologous but not identical to coagulation factors V and VIII is identified. Specific amino acid residue sequences of the receptor are described. Antibody compositions capable of immunoreacting with polypeptides containing the identified amino acid residue sequences and related diagnostic protocols are also described. The receptors are demonstrated to bind coagulation factor Xa which binding is inhibited by monoclonal antibodies to the receptors.

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