Cell surface tropomyosin as a target of angiogenesis inhibition

Details Cell surface tropomyosin as a target of angiogenesis inhibition Cell surface tropomyosin as a target of angiogenesis inhibition

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 38/12 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 1/22 (2006.01) C07K 7/64 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) G01N 33/566 (2006.01) G01N 33/58 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2478962

The present invention is directed to novel methods for inhibiting angiogenesis and treating tumors and cancer by targeting tropomyosin (Tpm) expressed on the surface of endothelial cells and/or tumor cells, to Tpm polypeptides and peptides, as well as variants and derivatives thereof that bind inhibitors of angiogenesis, and to anti-Tpm antibodies that block or stimulate angiogenesis. Cyclic peptides that bind to the D5 subunit of HKa and inhibit angiogenesis are also included. Method for screening test compounds as candidate antiangiogenic molecule that binds to Tpm are disclosed, as are affinity ligands comprising the proteins, peptides, variants and derivatives of the invention.

La présente invention concerne de nouveaux procédés d'inhibition de l'angiogenèse et de traitement de tumeurs et de cancers par ciblage de tropomyosine (Tpm) exprimée à la surface de cellules endothéliales et/ou tumorales. L'invention concerne également des polypeptides et peptides de tropomyosine, des variants et dérivés de ces polypeptides et peptides liant des inhibiteurs de l'angiogenèse, ainsi que des anticorps anti-tropomyosine bloquant ou stimulant l'angiogenèse. L'invention concerne par ailleurs des peptides cycliques se liant à la sous-unité D5 de HK¿a? et inhibant l'angiogenèse. L'invention concerne finalement un procédé de criblage de composés test en tant que molécule anti-angiogénique candidate se liant à tropomyosine, et des ligands par affinité contenant les protéines, peptides, variants et dérivés selon l'invention.

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