Cell tests and diagnostic index for alzheimer's disease

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) C07K 7/08 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12Q 1/02 (2006.01) G01N 33/53 (2006.01) G01N 33/543 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2200963

The present invention provides methods for the diagnosis of Alzheimer's disease using human cells. Specifically, one method detects differences between potassium channels in cells from Alzheimer's patient and normal donors, and differences in intracellular calcium concentrations between Alzheimer's and normal cells in response to chemicals known to increase intracellular calcium levels. Other methods detect differences between the memory associated GTP binding Cp20 protein levels between Alzheimer's and normal cells. In addition a diagnostic index for improved assessment between Alzheimer's and non Alzheimer's cells is provided.

Méthodes de diagnostic de la maladie d'Alzheimer mettant en oeuvre des cellules humaines. De manière spécifique, l'une de ces méthodes consiste à détecter les différences présentées par les canaux potassiques des cellules chez un patient atteint de la maladie d'Alzheimer et chez des donneurs sains, et les différences que présentent les concentrations de calcium intracellulaire des cellules chez le malade et chez un donneur sain en réponse à des substances chimiques dont on sait qu'elles augmentent les niveaux de calcium intracellulaires. D'autres méthodes détectent les différences que présentent les taux de protéines Cp20 liant le guanosine triphosphate associées à la mémoire dans les cellules d'un patient atteint de la maladie d'Alzheimer et d'un donneur sain. L'invention porte également sur un indice diagnostique permettant de mieux évaluer les cellules d'un malade et celles d'un donneur sain.

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