Cell transfecting formulations of small interfering rna,...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/87 (2006.01) C12N 15/113 (2010.01) A61K 31/713 (2006.01) A61K 47/06 (2006.01)

Patent

CA 2549720

Compositions incorporating small interfering ribonucleic acid (siRNA) and certain lipid-conjugated polyamide compound-based delivery vehicles that are particularly useful in the delivery siRNA and other polynucleotides to cells. Also, methods of making and using the compositions.

L'invention concerne des compositions incorporant un petit acide ribonucléique interférent (ARNsi) et certains vecteurs de distribution à base de composés de polyamide conjugués avec un lipide qui sont particulièrement utiles pour distribuer ledit ARNsi et d'autres polynucléotides à des cellules. L'invention concerne également des procédés de production et d'utilisation de ces compositions.

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