C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/86 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07K 16/30 (2006.01) C12N 7/01 (2006.01) C12N 15/867 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2184354
The present invention pertains to retroviral vector particles having target cell specificity which comprises a retroviral vector having a targeting peptide fused to the envelope protein of the retroviral vector to form a targeting envelope, wherein the targeting peptide replaces or disrupts the natural viral receptor binding site and the targeting peptide is the antigen binding site of an antibody, the receptor binding peptide of another virus, or is a peptide that specifically binds to a specific receptor of the target.
L'invention concerne des particules vecteurs rétrovirales, ciblant des cellules spécifiques, et notamment un vecteur rétroviral à protéine d'enveloppe fusionnée avec un peptide de ciblage pour donner une enveloppe de ciblage. Ce peptide de ciblage remplace ou désorganise le site de liaison au récepteur viral naturel, et le peptide de ciblage constitue le site de liaison à l'antigène d'un anticorps, le peptide de liaison à un récepteur propre à un autre virus, ou un peptide se liant exclusivement à un récepteur spécifique de la cible.
Sim & Mcburney
University Of Medicine & Dentistry Of New Jersey
University Of Medicine And Dentistry Of New Jersey
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