Cellobiohydrolase reduced glycosylation variants: cbhin45a;...

Details Cellobiohydrolase reduced glycosylation variants: cbhin45a;... Cellobiohydrolase reduced glycosylation variants: cbhin45a;...

C - Chemistry, Metallurgy

12

N

C12N 15/00 (2006.01) C12N 9/42 (2006.01)

Patent

CA 2379326

The invention provides a method for making an active exoglucanase in a eukaryotic heterologous host, the method comprising reducing glycosylation of the exoglucanase, wherein reducing comprises replacing an N-glycosylation site amino acid residue with non-glycosyl accepting amino acid residue. The invention further provides a cellobiohydrolase, comprising the reduced glycosylation variant cellobiose enzymes CBHIN45A; CBHIN270A; or CBHIN384A, or any combination thereof.

La présente invention concerne un procédé permettant de produire une exoglucanase active dans un système hôte hétérologue eucaryote. Ce procédé consiste à réduire la glycosylation de l'exoglucanase par remplacement d'un résidu d'acide aminé à site de N-glycosylation par un résidu d'acide aminé non glycosyle accepteur. Cette invention concerne également une cellobiohydrolase, comprenant les enzymes de cellobiose variantes à glycosylation réduite CBHIN45A, CBHIN270A ou CBHIN384A, ou toute combinaison de ces dernières.

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